First Genetic Study of Stretch Marks



A new study is the first of its kind to look at the genetics of striae distensae, otherwise known as stretch marks. The study, conducted by the genetic testing company 23andMe, discovered four genetic markers and a strong association between elastin and stretch marks. This research could provide the platform to improve methods of prevention and treatment.

Stretch marks are a type of scarring that appears on the skin in the form of pink, red or purple indented streaks. The marks typically appear after pregnancy, rapid weight gain or loss, or growth spurts. Many factors are believed to contribute to stretch marks including genetics, excessive skin distension and prolonged exposure to cortisol.

23andMe conducted a genome-wide association analysis across 33,930 unrelated people of European descent. There were a total of 13,930 people with stretch marks and 20,862 controls within the study. Researchers identified four genetic markers significantly associated with the development of stretch marks that could explain why some people are more susceptible to the skin condition.

The research also indicated that elastin could be the key to more effective prevention and treatment of stretch marks. The analysis identified an association between stretch marks and a variant near the ELN gene that encodes for the protein elastin. Defects in the gene are known to affect the integrity of the skin as well as cause heart defects. The study also identified an association between stretch marks and a variant in the SRPX gene, but more research is needed to understand how this could play a role in this condition.

"Through this first of its kind study, we've identified new genetic associations that can provide deeper insights into the root causes of stretch marks, and we look forward to continuing research in this space,” said Joyce Tung, Ph.D., author and 23andMe director of research. “One intriguing area for further study is the potential effect of genes associated with obesity on the development of stretch marks, both independent of and via changes in BMI. Replicating this work in a more precisely phenotyped population would also be a logical next step."

Popular treatments, including topical creams and laser removal, often focus on stimulating collagen production to decrease the appearance of stretch marks. Although the marks cannot be completely erased, these treatments can help fade stretch marks over time. To learn more or to find out how your stretch marks can be treated, please call to make an appointment with Greenville Dermatology today at (864) 242-5872.